Prediction of protein conformation.
نویسندگان
چکیده
منابع مشابه
Prediction of protein side-chain conformation by packing optimization.
We have developed a rapid and completely automatic method for prediction of protein side-chain conformation, applying the simulated annealing algorithm to optimization of side-chain packing (van der Waals) interactions. The method directly attacks the combinatorial problem of simultaneously predicting many residues' conformation, solving in 8 to 12 hours problems for which the systematic search...
متن کاملThe prediction of molecular conformation.
Although the art of predicting molecular conformation has not yet reached maturity, it is no longer in its infancy. On the one hand, model-building techniques taking account of van der Waals’ radii and hydrogen bonding have been used to interpret ambiguous experimental data, leading Pauling & Corey to the a-helix and B-pleated sheet, and Watson & Crick to the double helix of DNA. On the other h...
متن کاملPrediction of Protein Sub-Mitochondria Locations Using Protein Interaction Networks
Background: Prediction of the protein localization is among the most important issues in the bioinformatics that is used for the prediction of the proteins in the cells and organelles such as mitochondria. In this study, several machine learning algorithms are applied for the prediction of the intracellular protein locations. These algorithms use the features extracted from pro...
متن کاملCharacterizing protein conformation space
In this work, we propose a radical approach for exploring the space of all possible protein structures. We present techniques to explore the clash-free conformation space, which comprises all protein structures whose atoms are not in selfcollision. Unlike energy based methods, this approach allows efficient exploration and remains general – the benefits of characterization of the space apply to...
متن کاملA study of fragment-based protein structure prediction: biased fragment replacement for searching low-energy conformation.
A novel fragment replacement strategy for the fragment-based protein structure prediction is proposed. Despite the recent advance of de novo prediction of protein tertiary structure, intricate protein topologies still exist at unsatisfactory prediction quality. Although this difficulty is in part due to the accuracy of energy functions, it also relates to the search ability of sampling methods....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kobunshi
سال: 1985
ISSN: 0454-1138,2185-9825
DOI: 10.1295/kobunshi.34.978